SAN JOSE, Calif. and#8212; Chris Horner of Bend, Ore., powered to a solo uphill win in Stage 4 and assumed the overall race lead Wednesday at the Tour of California.

The 39-year-old Horner of the RadioShack team, last year finished 10th in the Tour de France as the top American. He completed the 81.8-mile Livermore to San Jose road race in 3 hours, 27 minutes, 51 seconds.

Andy Schleck (Leopard-Trek) of Luxembourg, the 2009 and 2010 Tour de France runner-up, finished second, 1:15 behind. Rory Sutherland (United Healthcare) of Australia was third, just behind Schleck.

Horner, fourth overall last year in the Tour of California, now leads the seven-day race by 1:15 over teammate Levi Leipheimer of Santa Rosa, Calif., the three-time race winner. Tom Danielson (Garmin-Cervelo) of Boulder, Colo., is third overall, trailing by 1:22.